Chancellor Wen-Hwa Lee, the Pioneer in the Field of Cancer Suppress Genes Elected the Fellow of The World Academy of Sciences

Date: December 3, 2018

Professor Wen-Hwa Lee, the Chancellor of China Medical University and an expert in cancer biology, was elected the membership of The World Academy of Sciences (TWAS) Fellow in 2018. Chancellor Lee’s long-time dedication to the research of cancer suppress genes has received outstanding results and has made great contribution to health promotion and cancer prevention. Chancellor Lee has made CMU faculties and students proud of being part of this big family.

The World Academy of Sciences held its 28th General Meeting in Trieste, Italy from November 27th to 29th. Over 200 fellows from over 90 countries exchanged ideas about the new trend in international scientific research and development. On 29th, a charter ceremony was held for the new selected fellows of 2018. Three fellows from Taiwan were inducted in 2018: Dr. Wen-Hwa Lee, Dr. Mei-Hwei Chang, and Dr. Sun-Lin Chung. They are among the world's most accomplished scientists and have made great contribution.

Chancellor Wen-Hwa Lee is a pioneer of tumor suppressor research in cancer biology. In 1986, he identified the first tumor suppressor gene, RB and showed that re-introduction of the gene suppressed neoplasm. His research also elucidated the function of two breast cancer susceptibility genes, BRCA-1 and 2, in modulating genomic stability.

The research team led by Chancellor Le recently published their research findings on “TGF-b1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB,EMBO Molecular Medicine”. The research confirmed that the elimination of Tregs in tumor‐draining LNs (TDLNs) can inhibit the activation of lymph node IL-17RB and reduce the toxicity of cancer cells. If TDLN is removed, the metastasis of breast cancer will be greatly reduced. This finding provided clear indication for physicians on making decision regarding whether to remove lymph nodes, and confirmed that developing IL-17RB antibody is the new direction for breast cancer treatment.

Moreover, another study done by the research team indicated that besides immune cell, adipocyte also promotes the growing of breast cancer cells. It is found that β-HB secreted by the adipocyte can facilitate the proliferation of breast cancer cells with MCT2 high gene expression. Therefore, aiming MCT2 as the treatment target may be a breakthrough for breast cancer treatment.

As an expert in the field of cancer genetics, Chancellor Wen-Hwa Lee was the nominee of the Nobel Prize in Medicine in the year of 1987. He was elected the member of the Academia Sinica in 1994, and the member of the American Association for the Advancement of Sciences in 2014. In addition, he has received many awards including the Outstanding Breast Cancer Research Award (Taiwan) and the Athalie Clarke Achievement Award (UC Irvine).

(Chinese Version.)


Chancellor Wen-Hwa Lee in the Charter Ceremony
Chancellor Wen-Hwa Lee
Chancellor Wen-Hwa Lee and Vice-president Lu-Hai Wang attended the 28th General Meeting of The World Academy of Sciences