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¤T»EÙæÓi¦M®`·ÀI
°²³]¨C¤ÑÁý¹À¦¨à240 g§t¦³¤T»EÙæÓiªº¥¤¯»±q¥X¥Í¦Ü¨â·³¡A¨ä·ÀI¦p¦ó¡H
¼Ðªº¦M®`°Ó¼Æ(Target hazard quotient, THQ; THQÈÀ³¤p©ó1)
[1]
°Ñ¼Æ |
C |
IR |
EF |
ED |
AT |
BW |
RfD |
³æ¦ì |
£gg/g |
g/day |
day/year |
years |
day |
kg |
mg/kg-day |
¼ÆÈ |
2.5, 14 |
240 |
365 |
2 |
730 |
7.9[2] |
0.63[3] |
C¡G¤T»EÙæÓi¿@«×(£gg/g)
IR¡G¨C¤éÄá¨ú¥¤¯»ªº¶q(g/day)
EF¡G¨C¦~¼ÉÅS¤Ñ¼Æ(365 day/year)
ED¡G¼ÉÅS¦~¼Æ(2 years)
BW¡GÀ¦¨à0¦Ü2·³ªº¥§¡Åé«(kg)
ATnc¡G«DPÀù¥§¡¤é¼Æ(ED ¡Ñ 365 day)
RfD¡G¹¤J°Ñ¦Ò¾¯¶q(mg/kg-d)
(1) ·í¥¤¯»¤¤ªº¤T»EÙæÓi¿@«×¬°2.5 ppm (£gg/g)
= 0.12
(2) ·í¥¤¯»¤¤ªº¤T»EÙæÓi¿@«×¬°20.7 ppm (£gg/g)
= 1.0
(3) ¤T³À¥¤¯»¤¤ªº¤T»EÙæÓi¿@«×¬°2600 ppm (£gg/g)
= 126
ªþµù¡G
[1] US EPA. Mercury Study Report to Congress Health Effects of Mercury and Mercury Compound, vol. V. Washington (DC): United States Environmental Protection agency; 1997 EPA-452/R-97-007.
[2] Lorber, M; Phillips, L. Infant exposure to dioxin-like compounds in breast milk. Environ Health Perspect. 2002 Jun;110(6):A325-32.
[3] The point of departure (POD) is the NOAEL of 63 mg/kg/day from the rodent subchronic bioassay. This POD was then divided by two 10-fold safety/uncertainty factors (SF/UF) to account for inter- and intra-species sensitivity, for a total SF/UF of 100. The resulting Tolerable Daily Intake (TDI) is 0.63 mg/kg bw/day. ( from Interim Melamine and Analogues Safety/Risk Assessment in FDA http://www.cfsan.fda.gov/~dms/melamra.html )
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